AST (Aspartate aminotransferase): the norm and viability. Aspartate aminotransferase (AST, AST): normal, increased blood level
Aspartate aminotransferase (AST) is an endogenous enzyme from the group of transferases present in all cells of the human body. However, the greatest amount of yoga is seen in the hearts and livers. If these cells collapse, then aspartate aminotransferase will be found in the blood, which can be used to diagnose the disease of these cells. If the liver and the heart are normal, then in the blood it is possible to detect only an insignificant amount of aspartate aminotransferase. The amount of human blood given to the enzyme is based on additional laboratory data.
Aspartate aminotransferase is normal. Deciphering the result (table)
Analysis for the appointment of aspartate aminotransferase (AST test) is prescribed for the diagnosis of liver disease in hepatitis, cirrhosis, or under treatment with various medical preparations, which can damage liver cells. Also, a blood test for AST is informative for the diagnosis of myocardial infarction.
The test for aspartate aminotransferase rіvle can be carried out either or included in the complex blood test, with the evaluation of the rіvnja іnshikh poknіnіkіv, zokrem ALT, zagalny blood protein, pudendal phosphatase, bilirubin. This allows you to more accurately determine the possibility of liver disease, as well as to control the effectiveness of the treatment that should be carried out after this recognition. Analysis of AST allows you to avoid overdosing drugs, which can cause damage to liver cells, so if necessary, take them and replace them for another time.
The appointment of aspartate aminotransferase is not necessary, as in case of death before the doctor, the patient suffers from pain in the stomach, disorder of poisoning, loss of appetite, swollen shkir, as in the case of a new one, zhovtyanitsa, dark slash and light feces are indicated. All signs of liver disease. Also, a blood test for AST should be carried out if there is a possibility of contact with a carrier of hepatitis, or if there is a previous infection of the liver.
Blood sampling is carried out from a vein, a wound, a nasche.
If aspartate aminotransferase is promoted - what does it mean
Significant increase in AST sounds is caused by viral ignition processes in the body. Significant shifts in AST are called, as if they exceeded the norm by 10 times or more. The same reaction can be caused by a damaged hemorrhage of the liver, or by the use of medicinal preparations, which induce the ear to the cells of the organ.
Although there are no more aspartate aminotransferase movements, lower in 4-5 times, we can talk about chronic hepatitis. Ale, an insignificant increase in the concentration of the enzyme can be caused by other illnesses, and itself:
- liver cirrhosis,
- evil puhlinnі utvorennia at the oven,
- destruction of liver tissue by metastases to another organ,
- mononucleosis and other viral diseases of the lymphatic system,
- obstruction of zhovchnyh passages and stasis of zhovchі in zhovchny mіkhurі - cholestatic syndrome,
- great opika,
- poisoning with toxic mushrooms,
- heatstroke,
- different injuries of the liver or injuries of the m'yaziv.
Therefore, in order to clarify the diagnosis, it is necessary to carry out additional obstezhennia of the patient. What is worth the myocardial infarction, then the most informative may be the assessment of the AST / ALT spontaneity. In case of low heart rate clitin, aspartate aminotransferase rіvn is significantly higher than ALT rіven. With ushkodzhenny clitin of the liver - navpaki. Wanting to experience and blame - hepatitis of alcohol withdrawal, cirrhosis of the liver and destruction of malignant cells.
Likewise, aspartate aminotransferase has been promoted, it may also appear after the introduction of medicinal preparations in the internal language or after the introduction of certain dietary supplements. Do not forget before taking the analysis ahead of your doctor about all the medicinal preparations and food additives that you took in the rest of the hour. Viklikati podvishchennya rivnya AST can be overly physical navantazhennya or m'yazova activity in the course of advanced training.
It is important - in children, the rise of aspartate aminotransferase in the blood can be caused by some kind of ignition disease. Therefore, as the analysis shows similar results, it is necessary to carry out additional obstezhennia and clarify the diagnosis.
If aspartate aminotransferase is reduced - what does it mean
The biggest reason for the decrease in aspartate aminotransferase is the deficiency of vitamin B6 in the human body. If we talk about the possibility of illness, then the AST rivulet can be reduced in case of great liver injuries, cirrhosis and tissue necrosis.
Physiologically, a decrease in the level of aspartate aminotransferase depends on the hour of vagity. This is absolutely normal, it is not pathology that is not guilty of causing anxiety in future mothers.
Aspartate aminotransferase (AST) is an enzyme that is found in all cells of the body, and is the main rank in the cells of the heart and liver and lesser in the world in nirkah and m'yazakh. In norm, the activity of AST in the blood is rather low. With poor tissue of the liver, or m'yazіv won't vibrate at the blood. In this rank, AST is a sign of the liver's ear.
Synonyms of Russian
Glutamine-oxaloacetate transaminase in sirovattsі, glutamate-oxaloacetate-transaminase of blood serum (SGOT), aspartate transaminase, spivvіdnoshenna AST/ ALT.
Synonyms of English
Aspart aminotransferase.
follow-up method
UV kinetic test.
Alone in the world
Od/l (one per litre).
What kind of biomaterial can be collected for follow-up?
Venous, capillary blood.
What is the right way to get ready for the deadline?
- Don't get used to it for 12 years before the deadline.
- Turn on the physical and emotional overvoltage by stretching 30 strands to the finish.
- Do not fire 30 strands to the building of blood.
General information about the follow-up
Aspartate aminotransferase (AST) is an enzyme that is found in all cells of the body, a protein in the heart and liver and in the lesser world in nirkah and m'yazah. In healthy patients, the activity of AST in the blood is low and the norm of AST is low. When the liver is damaged or m'yaziv AST vivilnyaetsya, instead of AST in the blood moves. In connection with cym, the activity of the enzyme is an indication of liver damage. The analysis for AST is included in the storage of liver samples - after diagnosis, damage to the robotic liver is diagnosed.
The liver is an important organ of life, spread at the upper right part empty stomach. She takes part in the important functions of the body - assists in the processing of living speech, the production of chewing gums, the synthesis of important proteins, such as factors in the system of blood glottis, and also breaks down potentially toxic half-lives to harmless speech.
A number of illnesses cause the liver cells to become weak, which will increase the activity of AST.
The most common analysis for AST is prescribed to check if the liver is damaged through hepatitis, the use of toxic drugs, cirrhosis. Prote AST, which is more likely to kill the liver, the activity of this enzyme can be increased in diseases of other organs, the cream in case of myocardial infarction.
New victorious dosledzhennya?
- For revealing the ear of the liver. As a rule, the test for AST is prescribed at the same time as the analysis for alanine aminotransferase (ALT) or warehouse part global analysis functioning of the liver. AST and ALT are considered by the two most important indicators of liver damage, although ALT is more specific, lower AST. In some cases, AST is immediately registered with ALT, and their spontaneity (AST / ALT) is counted. There can be a vikoristane to explain the reasons for liver damage.
- The indicator of AST in blood is often set with the results of other analyses, for example, pool of phosphatase (LF) , glowing proteinі bilirubin, for specific forms of disease of the liver.
- To control the effectiveness of the lіkuvannya disease of the liver.
- To protect the health of patients, as they take faces that are potentially toxic to the liver. If the activity of AST is moving, the patient can be transferred by taking other drugs.
When is due due?
- With symptoms of liver disorder:
- weakness, stubbornness,
- lose your appetite
- nudoti, vomit,
- pain in the stomach and yogo zduttya,
- pozhovtinnya shkir and eye whites,
- section of dark color, light style,
- sverbіnnya.
- For the obvious factors that increase the risk of blaming liver disease:
- previous hepatitis or recent contact with hepatitis infection,
- transcendental alcohol,
- spadkovoї smilnostі to zahvoryuvan liver,
- accept likiv, yakі can chew the liver,
- supraworld vase or diabetes.
- On a regular basis, through the whole process of exaltation, the determination of its effectiveness.
What do results mean?
Reference value (AST norm for people, women and children):
Normally, the activity of AST in the blood is low.
Overworldly high activity of AST (greater than 10 times greater than the norm) is associated with viklikana viral infections. Also, it can significantly increase in the past when taking likiv or other speeches, which are toxic to the liver, and also through ailments, which increase blood flow to the liver (ischemia).
In chronic hepatitis, AST activity rises above the norm by more than 4 times. Vaughn kolivaetsya mizh normal that deshcho promoted, that often for z'yasuvannya stage zahvoryuvannya that analysis is assigned. Such an illness, like the obstruction of the zhovchnyh paths, cirrhosis and deyaki, see liver cancer, succumb to the peaceful advancement of AST. After suffering a heart attack, and in case of minor illness, the activity of AST can also rise, sounding richer than ALT.
With more liver disease, ALT activity in the blood is more than AST activity, so the AST/ALT response will be low. Proteo є kіlka vynyatkіv: alcoholic hepatitis, cirrhosis and ushkodzhennya m'yazіv.
Important respect
- With vagity, AST activity may decrease.
- Intravenous drug use, as well as intense physical pressure to increase the activity of AST in the blood.
- In some patients, liver failure and, as a result, an increase in AST activity can be caused by the intake of dietary supplements. Therefore, it is necessary to inform the doctor not only about all the flavors that are taken, but also about food additives.
Who assigns the due?
Therapist, cardiologist, hepatologist, gastroenterologist, general practitioner, surgeon, pediatrician.
Aspartate aminotransferase, or shortly AST or asat, is the name of an enzyme that is actively vicorated during the breakdown of almost all amino acids in the body. AST is seen in the heart cells, nirok, legenia, podshlunkovoj follicle, liver, brain, as well as in skeletal m'yazah. But the highest concentration of AST is present in the tissues of the liver and heart meat.
So, as this enzyme is established in the middle of the cell, in healthy people the concentration of aspartate aminotransferase in the blood is minimal, but if cells are aware of serious urticaria, large number the enzyme vibrates and is consumed in the deep blood circulation, which is fixed for the help of laboratory investigations. In this way we are in front of a trace of respect for those organs, like vengeance largest number AST. And that heart is a cookie.
Some serious illnesses can lead to an increase in the level of AST
Most often, myocardial infarction. The concentration of the enzyme in the blood can be increased to the norm by dozens of times. Moreover, the greater the rіven AST, the greater the cavity of the wound of the heart meat. Three days after the start of therapy, the analysis is repeated in order to review the effectiveness of the recognized treatment. The AST price may decrease.
Ruinive processes in the liver, caused by oncological diseases, alcohol abuse, obesity, hepatitis and other factors, are also accompanied by the rise of asat. To confirm the diagnosis, you need additional obstezhennia.
However, the rise of rіven asat can also be in a healthy person. For example:
- in children at different ignition processes;
- in pregnant women on the very cob of vagity;
- when taking various medications, such as barbiturates, valerian, antibiotics, paracetamol, antiseptic drugs, as well as taking alcohol.
What factors can affect the correctness of the analysis
It is also important to properly prepare before the sampling procedure, otherwise the result may be incorrect. It is necessary to know that:
- Blood sampling is prepared from a vein.
- It is necessary to give blood in a hurry. It is necessary to consult at least one year before the procedure.
- Do not follow the analysis of the AST rіven after the ultrasonic follow-up of the radiological obstezhennja.
- The minimum for doba is necessary to be carried out in the presence of alcoholic drinks. Don't fire any less in two years.
- If the patient is taking any medications, they should be taken immediately. As it is impossible, it is necessary to consult with a doctor, who has either undergone the procedure, or if you have injected the drugs that are taken on the body when deciphering the results of the analysis.
Reference (normal) values of asat concentration in blood serum
- children up to 1 year of age 25-75 units/l;
- children from 1 to 16 years old 15-60 od/l;
- women 1035 od/l;
- people 15 20 singles/l.
Also, rіven aspartate aminotransferase is an important indicator in the diagnosis and treatment of diseases of such organs, like a liver and a heart. However, there is a trace of memory that for the establishment of a diagnosis, additional obstezhennia is needed. The diagnostics and the examination of guilt should be carried out by the qualification of fahivtsy, until such a time you should seek help.
Transaminase is the main name of enzymes that are used in the middle cells of various organs. In case of ruined or damaged tissues, in case of injuries or pathologies, enzymes are released from cells, so blood levels rise.
The role of these proteins in the body is great: they take part in the process necessary for nitrogen and energy metabolism. Qi enzymes accelerate the transfer of amino groups from amino acids to keto acids.
The difference of transminase in the blood may be significant in diagnostics, shards are a sign of singing illnesses. Two types of enzymes, AST and ALT, are of particular importance in diagnostic practice. It may serve as a marker of damage to the liver, heart, and submucosa in the blood (the most common manifestations are hepatitis, myocardial infarction, pancreatitis). Їхні absolute values and spіvvіdnoshnіnіv іvnіv AST І ALT allow vyznáchit organ lesions, prostézhit the dynamics of the pathological process and establish the steps of the lesion.
For biochemical analysis venous blood sampling for transaminase
ALT
The new name for the enzyme is alanine aminotransferase. Name the reason why this protein can carry the amino acid alanine. Mainly brushed in the oven, as well as in the cells of the heart, pidshlunkovoj slough, nirok, m'yaziv.
Norm in the blood
For women and people, allowable values of difference:
- for women, the norm does not exceed 32 units / liter;
- for people - less than 40 units / liter.
For children of different age, the norms are changed:
- for the first five days of life - up to 49 units / liter;
- to pіvrok – 56;
- from pivroku to roku - 54;
- up to three times – 33;
- for three to six years - 29;
- from six to 12 - no more than 39.
Reasons for promotion
A high level of ALT is characteristic for such pathologies:
- liver cirrhosis;
- hostile hepatitis (viral, alcoholic);
- hostile pancreatitis;
- zlojakіsna pohіnki chi metastasis;
- mechanical zhovtyanitsa;
- swelling swelling;
- great heart attack;
- disease of the heart, in some cases, the collapse of clitin of the heart mass (heart failure, myocarditis);
- opika;
- great traumatic ushkodzhennya m'yaziv.
Insignificant progress is observed in such situations:
- after surgery on the heart;
- with uncomplicated infarction;
- chronic hepatitis;
- fatty hepatosis;
- mononucleosis.
Crimia of pathological reasons for the rise of ALT and physiological. Before them one can see:
- great physical excitement;
- taking certain medicinal drugs (antibiotics, valerian, echinacea, non-steroidal antiseptic drugs, contraceptives);
- taking certain dietary supplements that are negatively injected into liver cells;
- insignificant advancement can be observed in women in the first trimester (such a camp is considered normal);
- improper eating (presence in the diet of fast food, soda, drinks from manufactured products).
Transaminase ALT in the blood - a marker of liver disease
Of particular importance may be a symptom in the diagnosis of liver disease. A high level of ALT is a specific sign of hepatic pathology. As early as 1-4 days before the onset of symptoms in the blood, there are movements in the place of the enzyme. In times of severe disease of the liver, the veins exceed the norm more and less. How high rіven is saved by stretching a thriving hour, otherwise, at the later stages of illness, it grows, it is worth noticing about the massive destruction of liver tissues.
This pokanik allows you to reveal the same unsafe disease, like cirrhosis of the liver at an early stage. As a rule, during the last three hours the pathology does not show symptoms, and it is only possible to suspect such a diagnosis with the aid of a biochemical blood test for a high level of ALT. And here the norm is overwritten, ring out, vtrichi.
Analysis for ALT indications:
- when diagnosing pathologies of the liver, zhovchovivіdnyh tracts, pіdshlunkovoї zoloza;
- control of treatment of viral hepatitis;
- with differential diagnosis of hepatic and hemolytic zhovtyanitsy;
- with heart failure and other heart diseases;
- with pathologies of skeletal muscles;
- for an hour of obstezhennya blood of the donor.
The analysis is prescribed to people with onset symptoms:
- constant weakness;
- shvidko insists vtom;
- disgusting appetite;
- dark section and light feces;
- the yellowness of the shkiri and the white of the eyes;
- bloating;
- tedium of vomiting;
- bіl in the stomach.
An analysis for ALT can be prescribed to people who are trying to change the risk group:
- yakі mali contact іz ill for hepatitis;
- we are ill with blood diabetes;
- yakі mayut zayva vaga;
- suffering from alcohol addiction;
- how to take drugs with a toxic effect;
- people from the recessionary sickness to liver ailments.
It is important to know that a normal ALT level is also a guarantee of the presence of liver disease.
AST
AST, or aspartate aminotransferase, takes part in the transfer of the amino acid aspartate. It is important to take revenge at the heart, liver, nirkah, m'yazah.
Norm
- in women - from 20 to 40 units / liter;
- for people - from 15 to 31 units / liter;
- in newborns (5 deb) - up to 140 units / liter;
- for children up to nine years old - no more than 55 years.
The rise of AST in the blood is an important diagnostic sign of myocardial infarction
Reasons for promotion
Increased activity of AST in the blood is observed in such cases:
- with hepatitis of various types;
- myocardial infarction;
- myocarditis;
- inflammation of the heart meat in acute rheumatic fever;
- cancer of the liver and secondary puffs in the liver;
- cirrhosis and necrosis of the liver;
- alcoholism;
- autoimmune diseases of m'yaziv;
- pancreatitis (acute and chronic);
- zhovchnokam'yanoї ailments and other pathologies, with some disorders in the form of zhovchі;
- cholestasis;
- mononucleosis;
- hepatosis;
- opikah;
- heat stroke;
- poisoning with mushrooms;
- injury.
Most often, the indicator is victorious for diagnosing pathologies of the heart and liver. With the destruction of tissues of other organs of the yogo promotion, even if it is not possible to be considered a specific sign, do not become that great diagnostic value.
In case of myocardial infarction, AST in the blood goes up and down high equal stretching five deb, his ALT grows insignificantly. If the decrease is not seen after five days, we can talk about a poor prognosis, but if the rhіven increases, it is possible that the area of myocardial tissue necrosis has expanded.
Moves in place of AST in liver tissue necrosis. What is the meaning of yoga, it is harder to hit.
How do they cure liver ailments in a heart attack?
In order to analyze the blood, it is necessary to determine the level of AST / ALT in any organ - the myocardium and the liver - 1.3. If the value exceeds 1.3, it is a heart attack, if it is lower than the norm - hepatic pathology.
Visnovok
The significance of transaminase in the blood may be significant in the diagnosis of certain diseases. Zmist ALT is especially important in identifying hepatic pathologies of various walks. Change such an indication as AST in the case of an increase - an important diagnostic sign of myocardial dysplasia in myocardial infarction.
